Melon iconFrost icon

A better way to make
organisms better

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A better way to make
organisms better
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We’ve developed a breakthrough technology for modifying living things.

We’ve developed a
breakthrough technology
for modifying living things.

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Our platform can automatically control the evolution of microbes, making new therapeutics, materials, and food.

Our platform can automatically control
the evolution of microbes, making new
therapeutics, materials, and food.

We call our methodology “directed selection” — organism modification with an on-button.

We call our methodology
“directed selection” — organism
modification with an on-button.

Evolution is the most powerful designer of organisms.
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Technology

Our evolution steering platform is made up of maia™, our proprietary software,
and the Evolution Reactor™, our proprietary hardware.
Our evolution steering platform is made up of maia, our proprietary software, and the Evolution Reactor, our proprietary hardware.
Our evolution steering platform is made
up of maia, our proprietary software,
and the Evolution Reactor,
our proprietary hardware.
Evolution Reactor by Melonfrostupward arrowupward arrowdownward arrowdownward arrow
The Evolution Reactor can cultivate thousands of independent populations, measuring phenotypes and applying selection pressures.
The Evolution Reactor can
cultivate thousands of independent
populations, measuring phenotypes
and applying selection pressures.
That data is sent to
our software, maia.
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evolution reactor by melonfrost
Maia learns how the organisms evolve in response to selection pressures and sends instructions back to the Evolution Reactor.
Maia learns how the organisms
evolve in response to selection
pressures and sends instructions
back to the Evolution Reactor.
New pressures are applied, steering organismal evolution in real time.
New pressures are applied, steering
organismal evolution in real time.
Together, they form the
world’s first closed loop
automated system for
modifying traits
with evolution.
Together, they form the world’s first closed loop automated system for modifying traits with evolution.
Melonfrost Evolution Reactor Technical Drawing
Close-up of the Evolution Reactor
We can modify any trait we can measure in virtually any microbe, without knowing anything about their genetics.
We can modify any trait we can measure
in virtually any microbe, without knowing
anything about their genetics.
The changes we make are high fitness, meaning they will last longer with fewer unintended consequences.
The changes we make are high fitness,
meaning they will last longer with fewer
unintended consequences.
Illustration of cells
Rack of Evolution Reactors
Our platform is modular
and scalable.
Our platform is modular and scalable.
We're unlocking the power of biology to help solve some of the world's toughest problems.
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About

Cells are some of the most powerful tools on the planet.
We’re replacing genetic scalpels and stitches with an evolutionary steering wheel, to unleash the full potential of synthetic biology.
melonfrost logo

Team

Sam and Loren went to pre-school together. Two decades later, when Sam was at Oxford and Loren was at Stanford, they hatched an idea for a new way to modify organisms. With the help of two other childhood friends, they created Melonfrost.
Samuel Levin PhD
CEO
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Sam did his PhD on the origin of life at Oxford.
Loren Amdahl-Culleton MS
Head of Engineering & Design
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Loren designed electromechanical systems and reinforcement learning algorithms at Stanford.
Luc Harrigan MSc
Head of Operations
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Luc studied international conflict at LSE, and has managed both digital and physical infrastructure projects for fortune 500 companies.
Sasen Efrem MSc
Senior Scientist, Biochemistry
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Sasen is a McGill trained pharmacologist, whose experience ranges from developing targeted viruses for Alzheimer's to establishing covid antigen assays.
John Varga PhD
Senior Scientist, Microbiology
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John has over 20 scientific publications, and has worked at Georgia Tech, Emory, and the Craig Venter institute.
Raman Ganti PhD
Senior Scientist, Machine Learning
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Raman completed his PhD at Cambridge University and a postdoc at MIT where he worked on optimizing fitness landscapes for vaccine design.
Pierre Enel PhD
Senior Scientist, Machine Learning
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With a PhD in computational neuroscience and postdocs at Mount Sinai and NYU, Pierre has leveraged machine learning to analyze and model the brain for more than 10 years prior to joining Melonfrost.
Tony Zhang BSE
Software Engineer
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After getting his degree in Biomedical Engineering and Computer Science from Case Western Reserve University, Tony spent 7 years developing state of the art software tools for Philips Healthcare.
Sean White BA
Ops & Finance Manager
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Sean spent years traveling the globe teaching English, roofing, writing freelance, and working service. He is an avid boxer and Risk player.

Advisors

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Paul Sekhri ➛
CEO, vTv Therapeutics
Prof. Stuart West ➛
Evolutionary Biology, Oxford University
Dr. Pierre-Luc Bacon ➛
Computer Science, University of Montreal
Jed Dean ➛
Co-Founder, Zymergen

Supported by

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Also
Nat Turner and Zach Weinberg
Founders of Flatiron Health
Jeff Dean
Lead of Google AI
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Contact

Get in touch

If you're interested in partnering with us or learning more, e-mail us at: evolve@melonfrost.com
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